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From the 162 families, the researchers selected 417 subjects who were diagnosed with schizoaffective/bipolar disorder, bipolar I disorder or bipolar II disorder.
These subjects were asked whether they had ever attempted suicide and the degree of intent of the most serious attempt. One hundred fifty-four subjects said they had attempted suicide, and 122 stated that they had â??definiteâ? intent. For the purpose of this study, the latter were considered to have a history of attempted suicide.
Data for all 417 subjects was entered into a computer program that looks for genetic similarities between subjects with similar psychological profiles. Results indicated that family members with a history of attempted suicide and bipolar disorder showed a high degree of genetic similarity at a specific area -- DNA marker D2S1777 -- on a section of chromosome 2 referred to as 2p12. This is the same marker implicated in a 2004 study from the University of Pittsburgh School of Medicine that looked at attempted suicide and major depression. And it is close to another marker, D2S1790, located in the 2p11 region of chromosome 2, which was identified in a 2004 study from the University of Connecticut School of Medicine that looked at alcoholism and attempted suicide.
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