Not sure what exactly you mean by settings, but for me, (iphone though) chrome works ok-ish, though it crashes every now and then with too many tabs open. I get more reliable connections with the safari browser, ironic as that may sound. But chrome in icognito mode should work fine if you dont put too much strain on it by having 10 tabs open.
As far as I'm aware the mobile version of the site works as well as the desktop version, and has all the same features. The only thing I've occassionally found to be buggy is the text editor / reply field itself, but those have never worked flawlessly for me on any forum website. I'd recommend writing things in your favourite note-taking app and copying it over once it's ready to be posted, but aside from that I don't think there are any mobile-specific settings/precautions.